This study was performed to inspect the demographic and epidemiological characteristics of female reproductive cancers in Northern Iran in comparison with relevant studies. The mean (SD) age of these patients was 53.45(14.32) years. In this study, 18% of subjects were 50-54 years. Our findings showed that female reproductive cancers incidence are more in urban than rural, which was in line with the findings of NegarSadat Taheri et al3. Our study showed that the frequency of female reproductive cancers according to residents of cities and villages in Mazandaran province is 57.4% and 45.3%, respectively. This may be elucidated b differences in lifestyle, genetic factors6, 7 and socioeconomic status3. However, future studies are needed to discover the true etiology of this difference. Our results showed the mean age (SD) of these patients according to involved organs 53.45 years. The most frequent in corpus uterus and ovary groups were 56.70 and 52.04 years, respectively. Furthermore, the differences of between these cancers groups were not significant (p=0.179). According to this study, the incidence rate of the cancer of the uterus was 2.58 per 100000 persons-year, which was in line with a population-based study in the Golestan province in North of Iran3. While in America the overall incidence of this cancer increased 8. The ASR of cervical cancer in Mazandaran female was 1.48 per 100000 persons-year, which was in line with the findings of developed countries. This low incidence rate maybe may be elucidated by appropriate medical education and protected sexual behaviors or implementation of effective controlling programs such as screening programs in Mazandaran province. Our results showed that the ASR of ovarian cancer was 2.65 per 100000 persons-year. It was not similar to the rates reported for Golestan province in the north of Iran3. This difference may be related to genetic high geographical variations in the field of cancer5. According to our study, differences between of frequency of uterus and ovary cancers with tumor behavior (in situ and malignant primary site) were significant (p=0.046). In conclusion, we found higher rates of reproductive cancers incidence in urban than rural. The incidence rate of cervical cancer in Mazandaran province is low and the ASR of cervical cancer in Mazandaran female was in line with the findings of developed countries. We found significant differences between of frequency of uterus and ovary cancers with tumor behavior. A limitation of our study was its cross-sectional nature and its large sample size was a strength.